S. M. Faisal

Epigenetic reprogramming of autophagy leads to uncovering a novel therapeutic target for mutant IDH1 astrocytomas

This study identifies autophagy as a critical survival pathway in mIDH1 gliomas and shows that inhibiting autophagy enhances radiosensitivity and tumor regression in preclinical models.

Modeling Glioma Oncostreams In Vitro: Spatiotemporal Dynamics of their Formation, Stability, and Disassembly

This paper models glioma oncostreams in vitro, showing their formation, stability, and response to pharmacological agents, with insights into potential anti-invasion targets.

Systemic delivery of a CXCR4-CXCL12 signaling inhibitor encapsulated in synthetic protein nanoparticles for glioma immunotherapy

This paper develops synthetic protein nanoparticles delivering a CXCR4 inhibitor to treat glioma by enhancing immunotherapy and reducing tumor progression.

Screening of surface exposed lipoproteins of Leptospira involved in modulation of host innate immune response

The paper screens surface lipoproteins of Leptospira to identify their roles in modulating host innate immune activation or evasion, finding that Loa22 strongly activates macrophages while Lsa30 is least stimulatory.

Spatiotemporal analysis of glioma heterogeneity reveals Col1A1 as an actionable 1 target to disrupt tumor mesenchymal differentiation, invasion and malignancy

The paper identifies COL1A1 as a key driver of glioma mesenchymal differentiation and invasion, showing its inhibition disrupts tumor structure and improves survival.

Leptospira surface protein LigA plays a multifaceted role in modulating the host innate immune response

This study identifies the LigA surface protein's A11 domain as a key factor in Leptospira's ability to modulate host immune responses and evade complement-mediated killing.