Author

G. L. Seim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

J. Fan· 2 shared B. J. Erazo-Flores· 1 shared D. Pagliarini· 1 shared J. A. Votava· 1 shared J. Freeman· 1 shared J. Steill· 1 shared L. J. Knoll· 1 shared N. L. Arp· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

J. Fan

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Author profile →

2 papers

Recent·Most cited

Macrophages undergo functionally significant reprogramming of nucleotide metabolism upon classical activation

S. V. John, G. L. Seim, B. J. Erazo-Flores, J. Steill, J. Freeman, J. A. Votava, N. L. Arp, X. Qing, R. Stewart, L. J. Knoll, J. Fan

This study identifies significant reprogramming of nucleotide metabolism in classically activated macrophages, revealing key regulatory mechanisms and functional consequences.

bioRxiv · Dec 27, 2023 · PreprintCell Biology

Modifications of lipoic arm by reactive nitrogen species regulate α-ketoacid dehydrogenases

G. L. Seim, Z. Fang, D. Pagliarini, J. Fan

The paper shows reactive nitrogen species modify the lipoic arm of α-ketoacid dehydrogenases, inactivating them in macrophages and affecting mitochondrial metabolism.

bioRxiv · Jan 31, 2022 · PreprintBiochemistry