Author

N. L. Arp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Approach:Bayesian inference· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:mouse· 1

Frequent Co-Authors

J. Fan· 3 shared J. A. Votava· 2 shared X. Qing· 2 shared A. Huttenlocher· 1 shared A. R. Lynch· 1 shared A. S. Zhou· 1 shared A. Wagner· 1 shared B. A. Weaver· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

J. Fan

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Macrophages undergo functionally significant reprogramming of nucleotide metabolism upon classical activation

S. V. John, G. L. Seim, B. J. Erazo-Flores, J. Steill, J. Freeman, J. A. Votava, N. L. Arp, X. Qing, R. Stewart, L. J. Knoll, J. Fan

This study identifies significant reprogramming of nucleotide metabolism in classically activated macrophages, revealing key regulatory mechanisms and functional consequences.

bioRxiv · Dec 27, 2023 · PreprintCell Biology

Activation-induced shift in nutrient preference and function-specific nutrient dependence in human neutrophils

E. C. Britt, X. Qing, J. A. Votava, J. Lika, A. Wagner, S. Shen, N. L. Arp, H. Khan, S. M. Schieke, C. D. Fletcher, A. Huttenlocher, J. Fan

This study shows that human neutrophils shift nutrient preference from glycogen to glucose upon activation, with function-specific metabolic dependencies.

bioRxiv · Sep 25, 2023Biochemistry

Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenasecomplex and impact muscle cell metabolism

N. L. Arp, G. Seim, J. Josephson, J. Fan

This study shows reactive nitrogen species inhibit BCKDC by modifying its E2 subunit lipoic arm, leading to reduced BCAA oxidation and altered energy metabolism in muscle cells.

bioRxiv · Jul 31, 2023Biochemistry

Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference

A. R. Lynch, N. L. Arp, A. S. Zhou, B. A. Weaver, M. E. Burkard

This paper develops a framework to quantify chromosomal instability using agent-based modeling and Bayesian inference, validated with experimental data and applied to clinical samples.

bioRxiv · Apr 26, 2021Cancer Biology