L. J. Knoll

Host cell-specific metabolism of linoleic acid controls Toxoplasma gondii growth in cell culture

This study shows that Caco-2 cells support Toxoplasma gondii growth despite high linoleic acid levels, unlike human foreskin fibroblasts where LA inhibits parasite growth.

Macrophages undergo functionally significant reprogramming of nucleotide metabolism upon classical activation

This study identifies significant reprogramming of nucleotide metabolism in classically activated macrophages, revealing key regulatory mechanisms and functional consequences.

Recapitulating the life cycle of the global pathogen Entamoeba in mice

This paper develops a fecal-oral mouse model for Entamoeba histolytica using Entamoeba muris, showing oral infection, cyst shedding, and intestinal localization.

Kiss and spit metabolomics highlights the role of the host cN-II enzyme on purine metabolism during pathogen infection

The paper uses metabolomics to show that Toxoplasma gondii manipulates host metabolism via the cN-II enzyme during infection.

A potential Toxoplasma gondii lipoxygenase is necessary for virulence and associated with the host immune response

This study identifies TgLOX1 as a Toxoplasma gondii lipoxygenase essential for virulence, with its role in modulating the host immune response dependent on IFNγ.

RIPK3 facilitates host and pathogen interactions after oral Toxoplasma gondii infection

This study investigates the role of RIPK3 in host survival during oral Toxoplasma gondii infection, finding that RIPK3 deficiency improves survival despite higher parasite burden.

Intestinal delta-6-desaturase activity determines host range for Toxoplasma sexual reproduction

This paper identifies delta-6-desaturase activity as a determinant of species specificity for Toxoplasma gondii sexual reproduction, showing that feline intestinal lipid metabolism enables the sexual cycle while mice require dietary supplementation to achieve it.

Transcriptional analysis shows a robust host response to Toxoplasma gondii during early and late chronic infection in both male and female mice

The paper analyzes host transcriptional responses to Toxoplasma gondii in male and female mice during early and late chronic infection, finding sex-specific differences in gene expression and immune response.

Dual metabolomic profiling uncovers Toxoplasma manipulation of the host metabolome and the discovery of a novel parasite metabolic capability

This paper identifies a novel Toxoplasma enzyme that redirects carbon into ribose synthesis, bypassing NADP+ dependency, and highlights its potential as a drug target.