Integrative analyses uncover mechanisms by which aging drives B cell lymphoma
J. P. Castro, A. V. Shindyapina, A. Barbieri, K. Ying, O. S. Strelkova, J. A. Paulo, A. Tyshkovskiy, R. Meinl, C. Kerepesi, A. P. Petrashen, M. Mariotti, M. Meer, Y. Hu, A. Karamyshev, G. Losyev, , V. N. Gladyshev
This study identifies age-associated clonal B cells (ACBCs) as drivers of B-cell lymphoma in mice, linking aging-related epigenetic and cellular changes to cancer development and proposing mTOR/c-Myc inhibition as a therapeutic strategy.
bioRxiv · Feb 23, 2021 · PreprintCancer Biology