Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
6 papers
Recent·Most cited
L. Jayne, A. Lavin-Peter, J. Roessler, A. Tyshkovskiy, M. Antoszewski, E. Ren, A. Markovski, S. Sun, H. Yao, V. G. Sankaran, V. N. Gladyshev, R. T. Brooke, S. Horvath, E. C. Griffith, S. Hrvatin
This study shows that inducing a torpor-like state in mice slows blood epigenetic aging and improves healthspan by reducing core body temperature.
bioRxiv · Mar 20, 2024Physiology
Z. Zhang, X. Tian, J. Y. Lu, K. Boit, J. Ablaeva, F. T. Zakusilo, S. Emmrich, D. Firsanov, E. Rydkina, S. A. Biashad, Q. Lu, A. Tyshkovskiy, V. N. Gladyshev, S. Horvath, A. Seluanov, V. Gorbunova
This study shows that overexpressing the naked mole-rat HAS2 gene in mice increases hyaluronan levels, reduces inflammation, and extends lifespan and healthspan.
bioRxiv · May 4, 2023 · PreprintPhysiology
N. Oz, E. Vayndorf, M. Tsuchiya, S. McLean, L. Turcios-Hernandez, J. N. Pitt, B. W. Blue, M. Muir, M. G. Kiflezghi, A. Tyshkovskiy, A. Mendenhall, M. Kaeberlein, A. Kaya
The paper shows that overexpressing conserved essential genes in yeast increases replicative lifespan more than deleting them, suggesting essential genes are important for longevity.
bioRxiv · Mar 18, 2022Cell Biology
B. Zhang, D. E. Lee, A. Trapp, A. Tyshkovskiy, A. T. Lu, A. Bareja, C. Kerepesi, L. H. McKay, A. V. Shindyapina, S. E. Dmitriev, G. S. Baht, S. Horvath, V. N. Gladyshev, J. P. White
This study shows that prolonged heterochronic parabiosis reduces biological age and extends lifespan in mice through long-term epigenetic and transcriptomic changes.
bioRxiv · Nov 11, 2021Cell Biology
D. F. Bennett, A. Goyala, C. Statzer, C. W. Beckett, A. Tyshkovskiy, V. N. Gladyshev, C. Y. Ewald, J. P. de Magalhaes
This study identifies rilmenidine as a caloric restriction mimetic that extends lifespan in C. elegans by activating the I1-imidazoline receptor and modulating pathways involved in stress resistance and autophagy.
bioRxiv · Oct 13, 2021 · PreprintPharmacology & Toxicology
J. P. Castro, A. V. Shindyapina, A. Barbieri, K. Ying, O. S. Strelkova, J. A. Paulo, A. Tyshkovskiy, R. Meinl, C. Kerepesi, A. P. Petrashen, M. Mariotti, M. Meer, Y. Hu, A. Karamyshev, G. Losyev, , V. N. Gladyshev
This study identifies age-associated clonal B cells (ACBCs) as drivers of B-cell lymphoma in mice, linking aging-related epigenetic and cellular changes to cancer development and proposing mTOR/c-Myc inhibition as a therapeutic strategy.
bioRxiv · Feb 23, 2021 · PreprintCancer Biology