Cancer BiologybioRxivPreprint
Integrative analyses uncover mechanisms by which aging drives B cell lymphoma
J. P. Castro, A. V. Shindyapina, A. Barbieri…·V. N. Gladyshev
This study identifies age-associated clonal B cells (ACBCs) as drivers of B-cell lymphoma in mice, linking aging-related epigenetic and cellular changes to cancer development and proposing mTOR/c-Myc inhibition as a therapeutic strategy.
DOI 10.1101/2021.02.23.432500