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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
15 papers
Recent·Most cited
C. Z. Li, A. Haghani, Q. Yan, A. T. Lu, J. Zhang, Z. Fei, J. Ernst, X. Yang, V. N. Gladyshev, K. Raj, A. Seluanov, V. Gorbunova, S. Horvath
The paper develops DNA methylation predictors for mammalian maximum lifespan, gestation time, and sexual maturity, showing species-level epigenetic signatures that differ from individual lifespan variation.
bioRxiv · Nov 2, 2023 · PreprintEvolutionary Biology
Z. Zhang, X. Tian, J. Y. Lu, K. Boit, J. Ablaeva, F. T. Zakusilo, S. Emmrich, D. Firsanov, E. Rydkina, S. A. Biashad, Q. Lu, A. Tyshkovskiy, V. N. Gladyshev, S. Horvath, A. Seluanov, V. Gorbunova
This study shows that overexpressing the naked mole-rat HAS2 gene in mice increases hyaluronan levels, reduces inflammation, and extends lifespan and healthspan.
bioRxiv · May 4, 2023 · PreprintPhysiology
W. Liu, P. Zhu, M. Li, Z. Li, Y. Yu, G. Liu, J. Du, X. Wang, J. Yang, R. Tian, I. Seim, A. Kaya, M. Li, M. Li, V. N. Gladyshev, X. Zhou
This study uses comparative transcriptomics across mammals to show that longevity is influenced by polygenic and indirect selection, with key pathways like insulin signaling showing correlations with lifespan.
bioRxiv · Jan 9, 2023Evolutionary Biology
Q. Dou, A. A. Turanov, M. Mariotti, J. Y. Hwang, H. Wang, S.-G. Lee, J. A. Paulo, S. H. Yim, S. Gygi, J.-J. Chung, V. N. Gladyshev
This study shows TXNRD3 is essential for male fertility by regulating redox balance during spermatogenesis, as demonstrated through knockout mice and proteomic analysis.
bioRxiv · Dec 29, 2021 · PreprintBiochemistry
B. Zhang, D. E. Lee, A. Trapp, A. Tyshkovskiy, A. T. Lu, A. Bareja, C. Kerepesi, L. H. McKay, A. V. Shindyapina, S. E. Dmitriev, G. S. Baht, S. Horvath, V. N. Gladyshev, J. P. White
This study shows that prolonged heterochronic parabiosis reduces biological age and extends lifespan in mice through long-term epigenetic and transcriptomic changes.
bioRxiv · Nov 11, 2021Cell Biology
A. I. Alexandrov, E. V. Grosfeld, O. V. Mitkevich, V. A. Bidiuk, A. V. Nostaeva, I. V. Kukhtevich, R. Schneider, E. S. Shilov, V. V. Kushnirov, S. E. Dmitriev, V. N. Gladyshev
The paper identifies yeast mutants with increased cell death during division, revealing rapid stochastic necrosis linked to genetic perturbations and cell-wall integrity.
bioRxiv · Oct 20, 2021 · PreprintCell Biology
D. F. Bennett, A. Goyala, C. Statzer, C. W. Beckett, A. Tyshkovskiy, V. N. Gladyshev, C. Y. Ewald, J. P. de Magalhaes
This study identifies rilmenidine as a caloric restriction mimetic that extends lifespan in C. elegans by activating the I1-imidazoline receptor and modulating pathways involved in stress resistance and autophagy.
bioRxiv · Oct 13, 2021 · PreprintPharmacology & Toxicology
S. Emmrich, A. Trapp, F. Tolibzoda Zakusilo, M. Mariotti, M. E. Straight, Z. Zhang, S. Gray, M. G. Drage, Z. Ke, M. Takasugi, J.-H. Klusmann, V. N. Gladyshev, A. Seluanov, V. Gorbunova
This study identifies unique hematopoietic features in naked mole-rats, including myeloid bias and quiescent stem cells, linked to their exceptional longevity.
bioRxiv · Aug 1, 2021Cell Biology
S. Emmrich, F. Tolibzoda Zakusilo, A. Trapp, X. Zhou, Q. Zhang, E. M. Irving, M. G. Drage, Z. Zhang, V. N. Gladyshev, A. Seluanov, V. Gorbunova
This study shows that naked mole-rats lack thymic involution until midlife and have ectopic cervical thymi with distinct T cell composition compared to mice.
bioRxiv · Aug 1, 2021Immunology
H. Wang, Q. Dou, K. J. Jung, J. Choi, V. N. Gladyshev, J.-J. Chung
This study identifies TXNRD3's role in redox regulation during epididymal maturation, showing its impact on mitochondrial function and sperm motility in mice.
bioRxiv · Jul 19, 2021Physiology
C. Z. Li, A. Haghani, T. R. Robeck, D. Villar, A. T. Lu, J. Zhang, C. G. Faulkes, H. Vu, J. Ablaeva, D. M. Adams, R. Ardehali, A. Arneson, C. S. Baker, K. Belov, D. T. Blumstein, , A. J. Jasinska
The paper develops methylation-based models to predict maximum lifespan and other life history traits in mammals using data from 12,000 samples across 192 species.
bioRxiv · May 16, 2021 · PreprintEvolutionary Biology
A. Haghani, A. T. Lu, C. Z. Li, T. R. Robeck, K. Belov, C. E. Breeze, R. T. Brooke, S. Clarke, C. G. Faulkes, Z. Fei, S. H. Ferguson, C. J. Finno, V. N. Gladyshev, V. Gorbunova, R. G. Goya, , S. Horvath
This study analyzes DNA methylation across 11,117 samples from 176 species to identify modules related to traits like age, lifespan, and phylogeny, revealing epigenetic patterns across evolution and aging.
bioRxiv · Mar 16, 2021Evolutionary Biology
J. P. Castro, A. V. Shindyapina, A. Barbieri, K. Ying, O. S. Strelkova, J. A. Paulo, A. Tyshkovskiy, R. Meinl, C. Kerepesi, A. P. Petrashen, M. Mariotti, M. Meer, Y. Hu, A. Karamyshev, G. Losyev, , V. N. Gladyshev
This study identifies age-associated clonal B cells (ACBCs) as drivers of B-cell lymphoma in mice, linking aging-related epigenetic and cellular changes to cancer development and proposing mTOR/c-Myc inhibition as a therapeutic strategy.
bioRxiv · Feb 23, 2021 · PreprintCancer Biology
M. C. Sanchez-Lopez, N. Labadie, V. A. Lombardo, F. A. Biglione, B. Manta, R. S. Jacob, V. N. Gladyshev, S. Abdelilah-Seyfried, P. Selenko, A. Binolfi
The paper develops an NMR-based biosensor to measure MSRA and MSRB activities in vitro and in vivo, showing differences in substrate specificity between prokaryotic and eukaryotic MSRs.
bioRxiv · May 14, 2020Biophysics
S. Emmrich, M. Mariotti, M. Takasugi, M. E. Straight, A. Trapp, V. N. Gladyshev, A. Seluanov, V. Gorbunova
This study profiles the hematopoietic system of naked mole-rats at single-cell resolution, revealing unique stem cell features associated with longevity and cancer resistance.
bioRxiv · Nov 29, 2019 · PreprintImmunology