G. Mukherjee

Exploiting gene expression profiles of circulating extracellular vesicles for breast cancer detection

This study identifies five circulating extracellular vesicle RNAs that can diagnose breast cancer independently of subtypes and detect metastatic states.

Multiresolution molecular dynamics simulations reveal the interplay between conformational variability and functional interactions in membrane-bound cytochrome 2B4

This study uses multiresolution molecular dynamics simulations to show how conformational changes in CYP 2B4 affect ligand access and inhibitor binding.

O6-Alkylguanine-DNA Alkyltransferase Maintains Genomic Integrity During Peroxynitrite-Mediated DNA Damage by Forming DNA-Protein Crosslinks

This study identifies hAGT as a dual-function protein that repairs DNA damage and forms DNA-protein crosslinks to protect against peroxynitrite-induced genomic instability.

A Robust Deep Learning Approach for Joint Nuclei Detection and Cell Classification in Pan-Cancer Histology Images

This paper introduces TransNuc, a deep learning model for detecting and classifying cell nuclei in histology images, showing improved performance across various cancer types.

Comparative analysis of drug-salt-polymer interactions by experiment and molecular simulation improves biopharmaceutical performance

The paper combines experiments and molecular simulations to identify optimal drug-salt-polymer combinations for improving biopharmaceutical performance of poorly water-soluble drugs.

RICTOR Drives ZFX-mediated Ganglioside Biosynthesis to Promote Breast Cancer Progression.

This study identifies RICTOR's role in regulating ganglioside biosynthesis via ZFX and UGCG, promoting breast cancer progression through EGFR signaling.

Targeting "Immunogenic Hotspots" in Dengue and Zika Virus: A Novel Approach to a Common Vaccine

This paper identifies immunogenic hotspots common to Dengue and Zika viruses to design a multi-epitope vaccine, showing interactions with TLR4-MD2 complex.

An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase

This study investigates the structural and functional interactions between membrane-bound CYP 1A1 and CPR, identifying ET-compatible arrangements and explaining lower ET rates compared to bacterial CYPs.