A. Chakrabarty

O6-Alkylguanine-DNA Alkyltransferase Maintains Genomic Integrity During Peroxynitrite-Mediated DNA Damage by Forming DNA-Protein Crosslinks

This study identifies hAGT as a dual-function protein that repairs DNA damage and forms DNA-protein crosslinks to protect against peroxynitrite-induced genomic instability.

Leishmania major-induced alteration of host cellular and systemic copper homeostasis drives the fate of infection

This study shows Leishmania major manipulates host copper homeostasis to evade immune responses, while macrophages use copper to kill parasites.

GBMdeconvoluteR accurately infers proportions of neoplastic and immune cell populations from bulk glioblastoma transcriptomics data

This paper develops GBMdeconvoluteR, a tool to accurately infer neoplastic and immune cell proportions in bulk glioblastoma RNAseq data, validated against imaging mass cytometry.

IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy

This study identifies two IDHwt glioblastoma subtypes based on transcriptional response to treatment, with distinct resistance mechanisms and potential therapeutic implications.

Metalloprotease Gp63 targeting novel glycoside exhibits potential antileishmanial activity

This study identifies a glycoside derivative, Gly 2, with potent antileishmanial activity against Leishmania donovani, targeting the metalloprotease Gp63 and showing efficacy against both visceral leishmaniasis and post-kala-azar dermal leishmaniasis.

JARID2 facilitates transcriptional reprogramming in glioblastoma in response to standard treatment

The paper identifies JARID2-mediated transcriptional reprogramming in glioblastoma post-treatment, showing dysregulated genes with JARID2 binding sites are universally altered in recurrent tumors.