Author

Z. C. Lorson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

H. Zhang· 2 shared S. G. Sarafianos· 2 shared A. Emanuelli· 1 shared A. Emanuelli Castaner· 1 shared G. Neilsen· 1 shared J. Fahim· 1 shared J. Lee· 1 shared K. A. Kirby· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

H. Zhang

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2 papers

Recent·Most cited

TSAR, Thermal Shift Analysis in R, identifies endogenous molecules that interact with HIV-1 capsid hexamers

W. M. McFadden, X. Gao, Z. Ye, X. Wen, Z. C. Lorson, H. Zhang, J. Fahim, A. Emanuelli, K. A. Kirby, S. G. Sarafianos

TSAR streamlines thermal shift assay analysis, identifying gallic acid and other metabolites that interact with HIV-1 capsid hexamers and may inhibit HIV-1 replication.

bioRxiv · Nov 29, 2023 · PreprintBiochemistry

Nirmatrelvir Resistance in SARS-CoV-2 Omicron_BA.1 and WA1 Replicons and Escape Strategies

S. Lan, G. Neilsen, R. L. Slack, W. A. Cantara, A. Emanuelli Castaner, Z. C. Lorson, N. D. Lulkin, H. Zhang, J. Lee, M. E. Cilento, P. R. Tedbury, S. G. Sarafianos

This study identifies E166V as a key mutation conferring high nirmatrelvir resistance in SARS-CoV-2, with differential effects on Omicron and WA1 variants, and explores strategies to overcome resistance.

bioRxiv · Dec 31, 2022 · PreprintMicrobiology