G. Purvis

OxPhos in adipose tissue macrophages regulated by BTK enhances their M2-like phenotype and confers a systemic immunometabolic benefit in obesity

This paper shows that inhibiting BTK in adipose tissue macrophages enhances OxPhos and shifts macrophages to an M2-like state, reducing inflammation and improving metabolic outcomes in obesity.

Ly6Chi monocytes are metabolically reprogrammed in the blood during inflammatory stimulation allowing for macrophage lineage commitment

The paper shows Ly6Chi monocytes undergo metabolic reprogramming during inflammation, enabling macrophage lineage commitment through oxidative phosphorylation.