OxPhos in adipose tissue macrophages regulated by BTK enhances their M2-like phenotype and confers a systemic immunometabolic benefit in obesity
G. Purvis, M. Collino, A. Van Dam, G. Einaudi, Y. Ng, M. Shanmuganathan, S. Patel, C. Thiemermann, K. Channon, D. Greaves
This paper shows that inhibiting BTK in adipose tissue macrophages enhances OxPhos and shifts macrophages to an M2-like state, reducing inflammation and improving metabolic outcomes in obesity.
bioRxiv · Oct 9, 2023Pathology