Author

K. Channon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Greaves· 2 shared G. Purvis· 2 shared A. Ansari· 1 shared A. L. McNaughton· 1 shared A. Van Dam· 1 shared B. L. Turnes· 1 shared B. Wright· 1 shared C. J. Woolf· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersPathology

D. Greaves

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

OxPhos in adipose tissue macrophages regulated by BTK enhances their M2-like phenotype and confers a systemic immunometabolic benefit in obesity

G. Purvis, M. Collino, A. Van Dam, G. Einaudi, Y. Ng, M. Shanmuganathan, S. Patel, C. Thiemermann, K. Channon, D. Greaves

This paper shows that inhibiting BTK in adipose tissue macrophages enhances OxPhos and shifts macrophages to an M2-like state, reducing inflammation and improving metabolic outcomes in obesity.

bioRxiv · Oct 9, 2023Pathology

Mast cell-derived BH4 is a critical mediator of postoperative pain

P. Starkl, G. Jonsson, T. J. Artner, B. L. Turnes, N. Serhan, T. Oliveira, L.-M. Gail, K. Stejskal, K. Channon, T. Kocher, G. Stary, V. Klang, N. Gaudenzio, S. Knapp, C. J. Woolf, , S. J. F. Cronin

This study identifies mast cell-derived BH4 as a key mediator of postoperative pain, showing that substance P triggers BH4-dependent serotonin release in mast cells, and blocking substance P reduces pain.

bioRxiv · Jan 24, 2023 · PreprintImmunology

Ly6Chi monocytes are metabolically reprogrammed in the blood during inflammatory stimulation allowing for macrophage lineage commitment

G. Purvis, E. McNeill, B. Wright, S. Revale, H. Lockstone, K. Channon, D. Greaves

The paper shows Ly6Chi monocytes undergo metabolic reprogramming during inflammation, enabling macrophage lineage commitment through oxidative phosphorylation.

bioRxiv · Nov 15, 2021 · PreprintImmunology

Data from an electronic health informatics pipeline to describe clearance dynamics of Hepatitis B surface antigen (HBsAg) and e-Antigen (HBeAg) in chronic HBV infection

L. O. Downs, D. Smith, S. F. Lumley, M. Patel, A. L. McNaughton, J. Mokaya, A. Ansari, H. Salih, K. A. Varnai, O. Freeman, S. Cripps, J. Phillips, J. Collier, K. Woods, K. Channon, , P. C. Matthews

The paper describes an electronic health informatics pipeline that collects longitudinal clinical data on HBsAg and HBeAg clearance in chronic HBV infection, revealing demographic and treatment-related factors associated with clearance.

bioRxiv · Mar 26, 2019Microbiology