Author

T. R. Raghunand

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

R. P. Mukku· 3 shared C. V. Yeruva· 2 shared P. Kokavalla· 2 shared G. Ramachandran· 1 shared G. Swarup· 1 shared K. Chakraborty· 1 shared M. Savanagouder· 1 shared N. Nagarajan· 1 shared

Activity by Year

2023-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

R. P. Mukku

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 11, 2023

Optineurin is involved in regulating macrophage responses during mycobacterial infection

G. Ramachandran, C. V. Yeruva, G. Swarup, T. R. Raghunand

This study shows that optineurin deficiency impairs macrophage responses to mycobacterial infection by affecting autophagy and inflammatory cytokine production.

DOI 10.1101/2023.09.11.557134

mousebulk RNA-seq

𝕏 PostBluesky

MicrobiologybioRxivPreprintApr 7, 2023

The PPE25 (Rv1787)-PE18 (Rv1788)-PPE26 (Rv1789) gene cluster is involved in immune evasion by Mycobacterium tuberculosis

R. P. Mukku, P. Kokavalla, K. Chakraborty, T. R. Raghunand

This study identifies the PPE25-PE18-PPE26 gene cluster in Mycobacterium tuberculosis as involved in immune evasion by modulating cytokine levels and macrophage responses.

DOI 10.1101/2023.04.07.535983

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

MicrobiologybioRxivPreprintMar 31, 2023

Dissecting the Ca2+ dependence of Mycobacterium tuberculosis DesA1 function

M. Savanagouder, R. P. Mukku, U. Kiran…·T. R. Raghunand

This study investigates the role of Ca2+ in Mycobacterium tuberculosis DesA1 function, showing that Ca2+ binding stabilizes the protein and is essential for its activity and resistance to isoniazid.

DOI 10.1101/2023.03.31.535087

experimental assayprotein folding & dynamics

𝕏 PostBluesky

MicrobiologybioRxivPreprintMar 30, 2023

Delineating the functional role of the PPE50 (Rv3135) - PPE51 (Rv3136) gene cluster in the pathophysiology of Mycobacterium tuberculosis

R. P. Mukku, P. Kokavalla, S. Yadav, T. R. Raghunand

This study identifies the PPE50-PPE51 gene cluster in M. tuberculosis as promoting bacillary persistence through TLR1-dependent immunomodulation, reducing intracellular viability and increasing anti-inflammatory cytokine levels.

DOI 10.1101/2023.03.30.534876

humanproteomics

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MicrobiologybioRxivPreprintMar 20, 2023

Septum site placement in Mycobacteria - Identification and Characterization of mycobacterial homologues of Escherichia coli MinD

V. Kishore, S. S. G. Sharma, T. R. Raghunand

This study identifies and characterizes mycobacterial homologues of E. coli MinD, showing their role in septum formation and cell division in Mycobacterium tuberculosis and M. smegmatis.

DOI 10.1101/2023.03.20.533423

humanmouse

𝕏 PostBluesky