G.-B. Zhou

Degradation of SARS-CoV-2 receptor ACE2 by tobacco carcinogen-induced Skp2 in lung epithelial cells

The paper shows tobacco carcinogens increase ACE2 mRNA but reduce ACE2 protein levels via Skp2-mediated ubiquitination, decreasing SARS-CoV-2 infection in lung cells.

Genomic variations in paired normal controls for lung adenocarcinomas

This study identifies genomic variations in normal lung tissues paired with lung adenocarcinomas, revealing tobacco-induced DNA damage and associations with patient prognosis.