Autologous human iPSC-derived Alveolus-on-Chip reveals early pathological events of M. tuberculosis infection
Chak Hon Luk, Gabriel L. Conway, Kim Jee Goh, Antony Fearns, Irene Rodríguez Hernández, Nathan J. Day, Natalia Athanasiadi, Rocco D’Antuono, Enrica Pellegrino, Janick D. Stucki, Nina Hobi, Maximiliano Gabriel Gutierrez
A single-donor iPSC-derived alveolar chip with epithelial, endothelial and macrophage cells models early Mycobacterium tuberculosis infection and shows ATG14-deficient macrophages die more without extra bacterial replication.
Science Advances · Jan 1, 2026Peer-reviewedBioengineering✦ In-depth digest