Author

Chak Hon Luk

Centre National de la Recherche ScientifiqueORCID 0000-0002-5155-2257Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Antony FearnsiD· 2 shared Maximiliano Gabriel GutierreziD· 2 shared Camila ValenzuelaiD· 1 shared Camille CharoyiD· 1 shared Enrica PellegrinoiD· 1 shared Francisco Javier García-RodrígueziD· 1 shared Gabriel L. Conway· 1 shared Irene Rodríguez Hernández· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

Antony FearnsORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 6, 2026

ESX-1 remodels the Mycobacterium tuberculosis antigen storage compartment in macrophages

Chak Hon Luk, Tania Auchynnikava, Antony Fearns…·Maximiliano Gabriel Gutierrez

The paper investigates how Mtb remodels antigen storage compartments in macrophages using a split fluorescent protein reporter and subcellular spatial proteomics.

DOI 10.64898/2026.10.03.756392

humanproteomics

BioengineeringScience AdvancesPeer-reviewedJan 1, 2026

✦ In-depth digest

Autologous human iPSC-derived Alveolus-on-Chip reveals early pathological events of M. tuberculosis infection

Chak Hon Luk, Gabriel L. Conway, Kim Jee Goh…·Maximiliano Gabriel Gutierrez

A single-donor iPSC-derived alveolar chip with epithelial, endothelial and macrophage cells models early Mycobacterium tuberculosis infection and shows ATG14-deficient macrophages die more without extra bacterial replication.

10 citationstop 1%

humanbacteria (other)

MicrobiologybioRxivPreprintJan 8, 2025

SifA-mediated Remodeling of the Salmonella-Containing Vacuole Prevents Bacterial Dormancy by Promoting Nutrient Accessibility

Camila Valenzuela, Francisco Javier García-Rodríguez, Thomas Mazza…·Jost Enninga

This study identifies SifA as a key effector that prevents Salmonella dormancy by promoting nutrient accessibility through SIF-mediated remodeling of the Salmonella-containing vacuole.

DOI 10.1101/2025.01.08.631959

bacteria (other)experimental assay