Autologous human iPSC-derived Alveolus-on-Chip reveals early pathological events of M. tuberculosis infection
Chak Hon Luk, Gabriel L. Conway, Kim Jee Goh…·Maximiliano Gabriel Gutierrez
A single-donor iPSC-derived alveolar chip with epithelial, endothelial and macrophage cells models early Mycobacterium tuberculosis infection and shows ATG14-deficient macrophages die more without extra bacterial replication.