In situ generation of Aβ42 oligomers via secondary nucleation triggers neurite degeneration and synaptic dysfunction in human iPSC-derived glutamatergic neurons
Alicia González Díaz, Eleonora Sarracco, Andrea Possenti, Isaac Kitchen-Smith, Sean Chia, Joseph Menzies, Gabriel Stephenson, Rodrigo Cataldi, Kim Yahya, Yuqi Bian, Gustavo Antonio Urrutia, Sara Snogerup Linse, Benedetta Mannini, Michele Vendruscolo
This study generates Aβ42 oligomers in human iPSC-derived neurons to model Alzheimer's disease and assess inhibitor effects.
bioRxiv · Aug 30, 2024 · PreprintCell Biology