A human neuronal model of sporadic Alzheimer's disease induced by FBXO2 downregulation shows A β aggregation, tau hyperphosphorylation and functional network impairment
Alicia González Díaz, Andrea Possenti, Gustavo Antonio Urrutia, Yuqi Bian, Shekhar Kedia, Dorothea Böken, Christine Maria Lim, Danilo Licastro, Benedetta Mannini, David Klenerman, Michele Vendruscolo
This study shows that downregulating FBXO2 in human iPSC-derived neurons leads to Alzheimer's disease-like features including Aβ aggregation and tau hyperphosphorylation.
bioRxiv · Sep 1, 2024 · PreprintNeuroscience