Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewed
An antibiotic that mediates immune destruction of senescent cancer cells
Gabriele Casagrande Raffi, Jian Chen, Xuezhao Feng…·Liqin Wang
This paper identifies SLC25A23 as a vulnerability in senescent cancer cells and shows that salinomycin induces immunogenic cell death, enhancing immune destruction of these cells when combined with a DR5 agonistic antibody.
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