Cor Lieftink

The paper develops a high-throughput live-cell screening platform using time-lapse FRET-FLIM to study dynamic signaling phenotypes, demonstrating its effectiveness in identifying regulators of cAMP signaling.

The paper investigates the molecular and genomic effects of a global DNA damage tolerance defect, identifying type 3 deletions as a mutational signature of replication stress.

This paper identifies SLC25A23 as a vulnerability in senescent cancer cells and shows that salinomycin induces immunogenic cell death, enhancing immune destruction of these cells when combined with a DR5 agonistic antibody.

The paper identifies Fpt1 as a chromatin-associated regulator that promotes RNA Polymerase III eviction from tRNA genes in response to nutrient changes in yeast.

This study identifies PAXIP1 and STAG2 as co-regulators of the Glucocorticoid Receptor (GR) that maintain 3D genome architecture and enable stress hormone-dependent transcription.

This study shows that Cas9 expression levels significantly affect the efficiency and speed of large-scale pooled CRISPR screens, with higher Cas9 expression improving performance.