Bronchopulmonary Dysplasia with Pulmonary Hypertension Associates with Loss of Semaphorin Signaling and Functional Decrease in FOXF1 Expression
Shawyon P. Shirazi, Nicholas M. Negretti, Christopher S. Jetter, Alexandria L. Sharkey, Shriya Garg, Meghan Kapp, Devan J. Wilkins, Gabrielle Fortier, Saahithi Mallapragada, Nicholas E. Banovich, Christopher V.E. Wright, David B. Frank, Jonathan A. Kropski, Jennifer M. S. Sucre
The paper identifies loss of semaphorin signaling and reduced FOXF1 expression in BPD and BPD+PH using single-cell RNA sequencing and validates findings in a murine model.
bioRxiv · Aug 27, 2024 · PreprintGenomics