Shawyon P. Shirazi

This study shows that NK cell TGF-β signaling regulates postnatal lung development and BPD by affecting vascular patterning and senolytic activity.

This study shows that integrin α3β1 is essential for alveolar-capillary barrier formation by regulating epithelial differentiation during lung development.

AlveolEye improves lung morphometry by using computer vision to rapidly and reproducibly calculate MLI and ASVD from H&E images, reducing variability and increasing precision across observers.

The paper develops an ex vivo model of BPD using airway epithelial cells and identifies a molecular endotype characterized by vimentin expression and ciliary loss in infants with BPD.

This paper creates a spatial transcriptomic atlas of acute neonatal lung injury across development and disease severity using 1.2 million cells from 17 human infant lungs.

The paper identifies loss of semaphorin signaling and reduced FOXF1 expression in BPD and BPD+PH using single-cell RNA sequencing and validates findings in a murine model.