Author

Alexandria L. Sharkey

Vanderbilt University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Genomics· 1

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

Jennifer M. S. SucreiD· 3 shared Shawyon P. ShiraziiD· 3 shared Christopher S. JetteriD· 2 shared Jason J. GokeyiD· 2 shared Jeff ReeseiD· 2 shared Jonathan A. KropskiiD· 2 shared Nicholas M. NegrettiiD· 2 shared Shriya GargiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersDevelopmental Biology

Jennifer M. S. SucreORCID

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Author profile →

3 papers

Recent·Most cited

Integrin α3β1 is required for alveolar-capillary barrier formation through regulation of epithelial differentiation

Allison D. Henry, Annica L. Alwine, Matthew J. Niederhuber, Anika Yarlagadda, Nikita Muthakana, Angie L. Mordant, Jason J. Gokey, Jennifer M. S. Sucre, Austin J. Hepperla, Jeeyeon Cha, Peter M. Gulleman, Alexandria L. Sharkey, Naoko Boatwright, Seunghyi Kook, Jessica C. Lee, , Erin J. Plosa

This study shows that integrin α3β1 is essential for alveolar-capillary barrier formation by regulating epithelial differentiation during lung development.

bioRxiv · Oct 6, 2026 · PreprintDevelopmental Biology

AlveolEye: Rapid and precise lung morphometry guided by computer vision

Joseph Hirsh, Samuel Hirsh, Shawyon P. Shirazi, James Hirsh, Imani Douglas, Shriya Garg, Yeongseo Son, Arline Pierre-Louis, Claire Bunn, Christopher S. Jetter, T. James, Alexandria L. Sharkey, John T. Benjamin, Jason J. Gokey, Akihiro Ochi, , Nicholas M. Negretti

AlveolEye improves lung morphometry by using computer vision to rapidly and reproducibly calculate MLI and ASVD from H&E images, reducing variability and increasing precision across observers.

American Journal of Physiology-Lung Cellular and Molecular Physiology · May 1, 2026Peer-reviewedDevelopmental Biology

Bronchopulmonary Dysplasia with Pulmonary Hypertension Associates with Loss of Semaphorin Signaling and Functional Decrease in FOXF1 Expression

Shawyon P. Shirazi, Nicholas M. Negretti, Christopher S. Jetter, Alexandria L. Sharkey, Shriya Garg, Meghan Kapp, Devan J. Wilkins, Gabrielle Fortier, Saahithi Mallapragada, Nicholas E. Banovich, Christopher V.E. Wright, David B. Frank, Jonathan A. Kropski, Jennifer M. S. Sucre

The paper identifies loss of semaphorin signaling and reduced FOXF1 expression in BPD and BPD+PH using single-cell RNA sequencing and validates findings in a murine model.

bioRxiv · Aug 27, 2024 · PreprintGenomics