Jennifer M. S. Sucre

This study shows that lymphangiogenesis is essential for healing and survival after laryngotracheal injury in mice, as blocking it leads to worse outcomes.

This study shows that NK cell TGF-β signaling regulates postnatal lung development and BPD by affecting vascular patterning and senolytic activity.

This study shows that integrin α3β1 is essential for alveolar-capillary barrier formation by regulating epithelial differentiation during lung development.

The paper identifies DNA methylation changes in IPF lung epithelial cells linked to dysregulated transcriptional programs and impaired repair.

The paper combines two spatial transcriptomic chemistries to improve both sensitivity and coverage in a single tissue section, showing high concordance and enabling more comprehensive analysis.

AlveolEye improves lung morphometry by using computer vision to rapidly and reproducibly calculate MLI and ASVD from H&E images, reducing variability and increasing precision across observers.

The paper develops an ex vivo model of BPD using airway epithelial cells and identifies a molecular endotype characterized by vimentin expression and ciliary loss in infants with BPD.

This study shows RTEL1 regulates alveolar epithelial cell progenitor function but does not worsen experimental lung fibrosis in mice.

This paper creates a spatial transcriptomic atlas of acute neonatal lung injury across development and disease severity using 1.2 million cells from 17 human infant lungs.

Xenium profiling of 343 genes in 1,126,820 nuclei from 19 human lungs maps fibrosis niches and orders alveolar remodeling from alveolar-capillary disruption to SPP1+ macrophage accumulation.

The paper identifies loss of semaphorin signaling and reduced FOXF1 expression in BPD and BPD+PH using single-cell RNA sequencing and validates findings in a murine model.

The paper observes alveoli formation through epithelial outgrowth and mesenchymal rings in live lung slices, challenging the existing model of airspace subdivision.

The paper identifies a CXCL12 morphogen gradient in developing pulmonary vasculature, revealing endothelial heterogeneity and its role in vascular growth.

This study shows that blocking inflammation in preterm primates prevents lung injury, preserving alveolar structure and function similar to chronic lung disease in newborns.

The paper constructs a single-cell RNA sequencing atlas of lung development in mice, revealing cellular dynamics and transcriptional changes during the saccular to alveolar transition.

The paper identifies TMPRSS2 expression patterns in developing lungs and links them to SARS-CoV-2 infection susceptibility in different age groups.

Single-cell RNA-sequencing identifies distinct epithelial and mesenchymal cell types and their roles in pulmonary fibrosis.