Gabrielle Martinez

Studying the effect of conserved tyrosine phosphorylation within SH2 domains

This study investigates how phosphorylation at specific tyrosine sites within SH2 domains affects ligand binding, finding that phosphorylation at Y63 in PTPN11 reduces binding of physiologically relevant substrates.

A signaling inspired synthetic toolkit for efficient production of tyrosine phosphorylated proteins

The paper introduces a synthetic toolkit for efficiently producing tyrosine phosphorylated proteins by leveraging signaling-inspired targeting interactions.

CoDIAC: A comprehensive approach for interaction analysis reveals novel insights into SH2 domain function and regulation

The paper develops CoDIAC, a tool for analyzing domain interfaces, revealing new insights into SH2 domain function and regulation through phosphorylation and acetylation.