Robert W. Sprung

This study shows that daraxonrasib, a pan-RAS(on) inhibitor, effectively inhibits TNBC cell proliferation and tumor growth, either alone or in combination with a MEK inhibitor.

The paper develops a method to detect dynamic changes in enkephalin levels in mice during acute stress, revealing their release and correlation in the nucleus accumbens shell.

The paper introduces a synthetic toolkit for efficiently producing tyrosine phosphorylated proteins by leveraging signaling-inspired targeting interactions.

This study quantifies kinase protein abundance in human tissues using proteomic mass spectrometry, revealing heterogeneity in breast cancer subtypes and enabling clinical applications.

This study shows HTLV-1 infected T cells release small extracellular vesicles that promote bone loss by stimulating osteoclasts, independent of RANKL expression.