Reduced Cdc14 phosphatase activity impairs septation, hyphal differentiation and pathogenesis and causes echinocandin hypersensitivity in Candida albicans
Kedric L. Milholland, Ahmed AbdelKhalek, Kortany Maree Baker, Smriti Hoda, Andrew G. DeMarco, Noelle H. Naughton, Angela N Koeberlein, Gabrielle R. Lorenz, Kartikan Anandasothy, Antonio Esperilla-Muñoz, Sanjeev Kumar Narayanan, Jaime Correa‐Bordes, Scott D. Briggs, Mark C. Hall
This paper shows that reducing Cdc14 phosphatase activity in Candida albicans impairs cell wall integrity, septation, hyphal differentiation, and virulence, making it a potential antifungal drug target.
bioRxiv · Sep 29, 2022 · PreprintMolecular Biology