Gang Chen

This study shows hevin, an astrocyte-secreted protein, maintains chronic pain through NMDA receptor signaling, and neutralizing hevin may offer new therapeutic strategies for pain and neurodegeneration.

The paper identifies progenitor states and molecular programs in the zebrafish pMN domain using single-cell sequencing, revealing key genes involved in motor neuron and oligodendrocyte fate determination.

The paper identifies kenpaullone as a compound that enhances KCC2 expression and reduces pathologic pain by restoring inhibitory neurotransmission in mouse models.

This study shows IL-17 from glia suppresses inhibitory synaptic transmission and drives neuropathic pain after chemotherapy.