Gang Chen

A programmable mRNA platform for miRNA detection via miRNA-mRNA2 triplex-mediated ribosomal frameshifting

This paper develops a programmable mRNA platform that detects specific miRNAs by converting their presence into a quantifiable protein output through miRNA-triggered ribosomal frameshifting.

Dangling Ends of Third Strand and Duplex Drive Nucleic Acid Triplex Stabilization through Bimodal Association

This paper investigates triplex stability by showing that dangling ends from both the third strand and duplex enhance stability through bimodal association kinetics.

A new dual-affinity peptide nucleic acid for targeting miRNA-21 precursor rescues tumor repressor PTEN expression

This paper introduces a dual-affinity PNA (daPNA) platform that targets miR-21 precursor, inhibits Dicer activity, and rescues PTEN expression by blocking miR-21 maturation.

Towards the Development of Isoenergetic Peptide Nucleic Acid Based Probes Targeting Double-Stranded RNAs Through Enhancing Sequence-Specific Stacking Interactions

This paper investigates how modifying PNA with s2U adjacent to Q residues enhances binding affinity and functional activity toward dsRNAs, demonstrating broader applicability in targeting structured RNA structures.

Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform

This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.

Frameshift and wild-type proteins are highly similar because the genetic code and genomes were optimized for frameshift tolerance

The paper shows frameshift proteins are more similar to wild-type proteins than random, indicating the genetic code and genomes are optimized for frameshift tolerance.

A frameshift mutation is repaired through nonsense-mediated gene revising in E. coli

The paper reports that frameshift mutations in E. coli are repaired through a process called nonsense-mediated gene revising, which increases genetic diversity and accelerates evolution.