Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity
Jeehae Park, Javier Estrada, Gemma Johnson, Ben J. Vincent, Chiara Ricci-Tam, Meghan D. J. Bragdon, Yekaterina Shulgina, Anna Cha, Zeba Wunderlich, Jeremy Gunawardena, Angela H. DePace
The paper investigates the HbP2 enhancer in Drosophila, showing that cooperative binding of Bcd is insufficient to explain its sharp expression pattern, and identifies other factors like pioneer factors and histone modifiers as key contributors.
eLife · Jun 21, 2019Peer-reviewedGenetics