Non-cell-autonomous control of gastruloid development by the lncRNA T-UCstem1 through DKK1-dependent modulation of WNT signalling
Arianna Coppola, Filomena Amoroso, Federica Saracino, Gennaro Andolfi, Edoardo Sozzi, Paolo Salerno, Pietro Zoppoli, Alessandro Fiorenzano, Giuseppe Merla, Eduardo Jorge Patriarca, Gabriella Minchiotti, Annalisa Fico
This study identifies T-UCstem1 as a key lncRNA regulating gastruloid development through DKK1-dependent modulation of WNT signaling, affecting anteroposterior axis extension and cellular identity.
bioRxiv · Sep 18, 2024 · PreprintDevelopmental Biology