Giovanni D’Angelo

The lipidomic architecture of the mouse brain

The paper maps the lipidomic architecture of the adult mouse brain at micrometric scale, revealing spatial lipid organization and its functional relevance.

Molecular Regulation and Physiological Role of 1 GOLPH3-mediated Golgi retention

This study investigates the role of GOLPH3 in Golgi retention and trafficking, showing its regulation by S-acylation and its impact on glycosylation and development.

Ether lipid remodeling during neuronal differentiation prevents ferroptosis

This study shows that ether lipid remodeling during neuronal differentiation prevents ferroptosis by balancing pro- and anti-ferroptotic effects through vinyl ether bonds.

Actin dynamics sustains spatial gradients of membrane tension in adherent cells

The paper demonstrates that adherent cells maintain spatial gradients of membrane tension through actin dynamics and membrane-cortex attachments, with tension lowest at adhesion edges and highest at protrusions.

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

This study identifies a mechanical regulation pathway involving Src-FAK-AMPK-GBF1 that controls cargo sorting and secretion from the Golgi in response to substrate stiffness.

Unified Mass Imaging Maps the Lipidome of Vertebrate Development

The paper maps lipid distribution across vertebrate development using mass spectrometry imaging and reveals spatially organized metabolic circuits.

Positive selection in Europeans and East-Asians at the ABCA12 gene

The paper confirms a positive selection signal at the ABCA12 gene in Europeans and East-Asians and refines its genomic location, finding no direct effect on gene expression but tracing the T allele's trajectory in human history.