Edoardo Sozzi

The paper introduces a human stem cell-based model of the nigrostriatal pathway that mimics in vivo connectivity and reveals target-dependent dopamine neuron maturation.

This paper introduces 3D carbon cup electrodes for real-time, chemically selective detection of neurotransmitter release in midbrain organoids, demonstrating dopamine sensing and validating the platform with chemical perturbations.

The paper benchmarks dopaminergic stem cell models and cell therapy candidates using a human brain atlas to identify off-target populations and lineage plasticity.

This study investigates how co-grafting strategies influence dopamine neuron specification and maturation in a Parkinson's disease model, identifying key transcription factors involved in the process.

This paper describes a protocol for isolating nuclei from human stem cell-derived grafts in rat brains for single-nucleus RNA sequencing.

This study identifies T-UCstem1 as a key lncRNA regulating gastruloid development through DKK1-dependent modulation of WNT signaling, affecting anteroposterior axis extension and cellular identity.

The paper uses single-cell RNA sequencing to profile fetal human midbrain dopamine neurons at different developmental stages and establishes a 3D culture system to study their functional maturation.