Yali Xue

Himalayan whole-genome sequences provide insight into population formation and adaptation

The paper presents whole-genome sequences from 16 Himalayan populations to study population structure, adaptation, and genetic history, revealing early population divergence, shared adaptive haplotypes, and recent gene flow.

The Genomic History of the Middle East

This study analyzes 137 Middle Eastern genomes to reveal population history, ancestry, and selection patterns, showing no out-of-Africa expansions but elevated Basal Eurasian ancestry in Arabians.

A common 1.6 Mb Y-chromosomal inversion predisposes to subsequent deletions and severe spermatogenic failure in humans

The paper identifies a 1.6 Mb Y-chromosomal inversion in the AZFc region as a high-penetrant risk factor for male infertility, increasing the risk of spermatogenic failure by 8.6-fold.

The landscape of autosomal-recessive pathogenic variants in European populations reveals phenotype-specific effects

The paper estimates carrier rates and risk of severe autosomal recessive disorders in European populations using exome sequences.

Population Structure, Stratification and Introgression of Human Structural Variation.

The paper analyzes structural variation in 911 human samples from 54 populations, identifying novel variants and introgressed elements, and highlights the need for diverse high-quality genomes.

Insights into human genetic variation and population history from 929 diverse genomes

This study presents 929 high-coverage human genome sequences from 54 populations, revealing new insights into genetic variation and population history.

Early replacement of West Eurasian male Y chromosomes from the east

The paper uses Y-chromosome phylogenetic and phylogeographic analyses to show that non-African male lineages originated in East/South-east Asia 50,000-55,000 years ago, replacing earlier lineages.

Insight into the genomic history of the Near East from whole-genome sequences and genotypes of Yemenis

This study uses whole-genome sequences and genotypes from Yemenis to explore their genetic diversity and its relation to the Near East, finding limited geographic structure and widespread African admixture.

Positive selection in Europeans and East-Asians at the ABCA12 gene

The paper confirms a positive selection signal at the ABCA12 gene in Europeans and East-Asians and refines its genomic location, finding no direct effect on gene expression but tracing the T allele's trajectory in human history.

Latin Americans show wide-spread Converso ancestry and the imprint of local Native ancestry on physical appearance

The paper analyzes ancestry in Latin Americans using haplotype-based methods, finding widespread Converso ancestry and links between Native ancestry and facial features.

Continuity and admixture in the last five millennia of Levantine history from ancient Canaanite and present-day Lebanese genome sequences

This study analyzes ancient and modern genomes from the Levant to trace genetic continuity and admixture over five millennia, finding Canaanite-related ancestry and later Eurasian influences.

Health and population effects of rare gene knockouts in adult humans with related parents

The paper estimates the health effects of rare gene knockouts in adults by analyzing exome sequencing data and health records, finding no significant disease associations.

Genetic evidence for an origin of the Armenians from Bronze Age mixing of multiple populations

This study analyzes genome-wide variation in Armenians to show their origin from Bronze Age mixing of multiple populations and their genetic affinity to Neolithic Europeans.

Human genomic regions with exceptionally high or low levels of population differentiation identified from 911 whole-genome sequences

The paper identifies genomic regions with high or low population differentiation using 911 whole-genome sequences, finding that highly differentiated sites are enriched for positive selection.