A common TMPRSS2 variant protects against severe COVID-19
Alessia David, Nick Parkinson, Thomas P. Peacock, Erola Pairo‐Castineira, Tarun Khanna, Aurélie Cobat, Albert Tenesa, Vanessa Sancho‐Shimizu, GenOMICC Investigators, ISARIC4C Investigators, Jean‐Laurent Casanova, Laurent Abel, Wendy S. Barclay, John Kenneth Baillie, Michael J.E. Sternberg
This paper identifies a common TMPRSS2 variant that reduces the risk of severe COVID-19 by impairing SARS-CoV-2 entry into cells.
Current Research in Translational Medicine · Jan 10, 2022Peer-reviewedGenetic & Genomic Medicine