The paper integrates multi-omics data from pediatric sepsis patients to identify a reproducible inflammatory host-response axis associated with disease severity.

bioRxiv · Jul 13, 2026 · PreprintImmunology

Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei

Sydney L. Miles, Dilys Santillo, Hannah Painter, Kathryn Wright, Vincenzo Torraca, Ana T. López-Jiménez, Mollie Virgo, Xosé M. Matanza, Abigail Clements, Claire Jenkins, Stephen Baker, Kate S. Baker, David A. Cisneros, Andrea Puhar, Vanessa Sancho‐Shimizu, , Serge Mostowy

This study identifies enhanced virulence and stress tolerance as factors contributing to the epidemiological success of Shigella sonnei, using zebrafish models and genomic analysis.

Nature Communications · Oct 9, 2025Peer-reviewedMicrobiology

A common TMPRSS2 variant protects against severe COVID-19

Alessia David, Nick Parkinson, Thomas P. Peacock, Erola Pairo‐Castineira, Tarun Khanna, Aurélie Cobat, Albert Tenesa, Vanessa Sancho‐Shimizu, GenOMICC Investigators, ISARIC4C Investigators, Jean‐Laurent Casanova, Laurent Abel, Wendy S. Barclay, John Kenneth Baillie, Michael J.E. Sternberg

This paper identifies a common TMPRSS2 variant that reduces the risk of severe COVID-19 by impairing SARS-CoV-2 entry into cells.

Current Research in Translational Medicine · Jan 10, 2022Peer-reviewedGenetic & Genomic Medicine