Author

ISARIC4C Investigators

Hôpital Necker-Enfants Malades

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:variant effect prediction· 2 Assay:whole-genome sequencing· 2 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Organism:non-human primate· 1

Frequent Co-Authors

B. Jones· 2 shared C. Hartley· 2 shared H. Goldswain· 2 shared J. A. Hiscox· 2 shared J. K. Baillie· 2 shared L. Turtle· 2 shared M. Carroll· 2 shared M. G. Semple· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

B. Jones

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A common TMPRSS2 variant protects against severe COVID-19

Alessia David, Nick Parkinson, Thomas P. Peacock, Erola Pairo‐Castineira, Tarun Khanna, Aurélie Cobat, Albert Tenesa, Vanessa Sancho‐Shimizu, GenOMICC Investigators, ISARIC4C Investigators, Jean‐Laurent Casanova, Laurent Abel, Wendy S. Barclay, John Kenneth Baillie, Michael J.E. Sternberg

This paper identifies a common TMPRSS2 variant that reduces the risk of severe COVID-19 by impairing SARS-CoV-2 entry into cells.

Current Research in Translational Medicine · Jan 10, 2022Peer-reviewedGenetic & Genomic Medicine

Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype

X. Dong, H. Goldswain, R. Penrice-Randal, G. Shawli, T. Prince, M. K. Williamson, N. Randle, B. Jones, F. J. Salguero, J. Tree, Y. Hall, C. Hartley, M. Erdmann, J. Bazire, T. Jearanaiwitayakul, , J. A. Hiscox

The paper tracks the rapid emergence of the P323L mutation in SARS-CoV-2 polymerase in human and non-human primate models, showing it confers a larger plaque phenotype compared to P323.

bioRxiv · Dec 23, 2021 · PreprintMicrobiology

Sequence analysis of SARS-CoV-2 in nasopharyngeal samples from patients with COVID-19 illustrates population variation and diverse phenotypes, placing the in vitro growth properties of B.1.1.7 and B.1.351 lineage viruses in context.

T. Prince, X. Dong, R. Penrice-Randal, N. Randle, C. Hartley, H. Goldswain, B. Jones, M. G. Semple, J. K. Baillie, P. J. M. Openshaw, L. Turtle, ISARIC4C Investigators, G. Hughes, E. Anderson, E. I. Patterson, , J. A. Hiscox

The paper analyzes SARS-CoV-2 sequence variation in patient samples and compares the in vitro growth of B.1.1.7 and B.1.351 variants to other isolates, finding no significant difference in growth for B.1.1.7.

bioRxiv · Mar 30, 2021 · PreprintMicrobiology