Alessia David

The Topological Properties of the Protein Universe

The paper uses topology to analyze the protein universe, identifying structural and functional features and their implications for mutations and evolution.

Missense3D-PTMdb an interactive web resource to explore and visualize genetic variants and post-translational modifications sites (PTMs) using AlphaFold 3D models

Missense3D-PTMdb maps missense variants and PTM sites to AlphaFold 3D models to explore their structural and functional impacts.

The AlphaFold Database Ages

The paper highlights discrepancies between AlphaFold predictions and UniProt data, showing how bioinformatics resources can quickly become outdated.

A new web resource to predict the impact of missense variants at protein interfaces using 3D structural data: Missense3D-PPI

Missense3D-PPI predicts the impact of missense variants on protein-protein interfaces using structural data, showing improved sensitivity over previous methods.

A common TMPRSS2 variant protects against severe COVID-19

This paper identifies a common TMPRSS2 variant that reduces the risk of severe COVID-19 by impairing SARS-CoV-2 entry into cells.

The SARS-CoV-2 infection in Thailand: analysis of spike variants complemented by protein structure insights

This study analyzes SARS-CoV-2 spike variants from Thailand, finding that novel variants do not significantly alter spike structure or ACE2 binding, and p.D614G became prevalent in the second outbreak.

Random glucose GWAS in 493,036 individuals provides insights into diabetes pathophysiology, complications and treatment stratification

This study performs a GWAS on random glucose measurements in 493,036 individuals, identifying 128 loci associated with glycaemic traits and providing insights into diabetes biology and treatment.

Structure, function and variants analysis of the androgen-regulated TMPRSS2, a drug target candidate for COVID-19 infection

The paper analyzes TMPRSS2 variants and their potential impact on SARS-CoV-2 infection, showing that some variants may affect protein structure and function, and that TMPRSS2 and ACE2 are co-expressed in the gastrointestinal tract.