Apoptotic caspases silence spontaneous innate immune signals by specifically cleaving activated mitochondrial antiviral signalling protein (MAVS)
Sylwia Gradzka-Boberda, Ishita Parui, Pallab Chakraborty, Danielle Paige Anthony, Bhagya K. Puthussery, Arnim Weber, Dominik Brokatzky, Piero Giansanti, Julia Mergner, Rupert Öllinger, Roland Rad, Susanne Kirschnek, Ian Edward Gentle, Georg Häcker
This study shows caspase-3 cleaves activated MAVS to suppress spontaneous innate immune signaling in non-apoptotic cells.
bioRxiv · Feb 25, 2025 · PreprintCell Biology