Author

Susanne Kirschnek

University of FreiburgORCID 0000-0001-7771-7817Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Arnim WeberiD· 2 shared Roland RadiD· 2 shared Rupert ÖllingeriD· 2 shared Abdul MoeediD· 1 shared Aladin HaimoviciiD· 1 shared Bhagya K. Puthussery· 1 shared Daniela Neugebauer· 1 shared Danielle Paige AnthonyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Arnim WeberORCID

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2 papers

Recent·Most cited

Cell BiologyCell Death and DifferentiationPeer-reviewedFeb 3, 2026

The Second Mitochondrial Activator of Caspases (SMAC) regulates growth, inflammation and mitochondrial integrity in cancer cells

Tarek Amer, Aladin Haimovici, Susanne Kirschnek…·Georg Alexander Häcker

This study identifies SMAC as a regulator of cancer cell growth, inflammation, and mitochondrial integrity, showing its role in both apoptotic and non-apoptotic contexts.

1 citation

humanexperimental assay

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Cell BiologybioRxivPreprintFeb 25, 2025

Apoptotic caspases silence spontaneous innate immune signals by specifically cleaving activated mitochondrial antiviral signalling protein (MAVS)

Sylwia Gradzka-Boberda, Ishita Parui, Pallab Chakraborty…·Georg Häcker

This study shows caspase-3 cleaves activated MAVS to suppress spontaneous innate immune signaling in non-apoptotic cells.

DOI 10.1101/2025.02.25.640042

humanmouse

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