Rupert Öllinger

Modeling pancreatic cancer tumor stroma co-evolution in an in ovo model

This study uses an in ovo model to show that the CAM platform supports tumor-stroma coevolution in pancreatic cancer, preserving patient-specific features and enabling functional analysis of stromal interactions.

The Second Mitochondrial Activator of Caspases (SMAC) regulates growth, inflammation and mitochondrial integrity in cancer cells

This study identifies SMAC as a regulator of cancer cell growth, inflammation, and mitochondrial integrity, showing its role in both apoptotic and non-apoptotic contexts.

Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury

The paper shows that Treg cells use IFNγ and IL-10 to promote intestinal stem cell growth and repair after injury.

Profiling Nucleotide Signalling Pathways and STING Agonist Activity with a Nucleotide Library

The paper identifies 27 cyclic dinucleotides that activate STING, showing STING's preference for 2'3'-linked nucleotides and its ability to respond to non-hydrolysable isomers.

Apoptotic caspases silence spontaneous innate immune signals by specifically cleaving activated mitochondrial antiviral signalling protein (MAVS)

This study shows caspase-3 cleaves activated MAVS to suppress spontaneous innate immune signaling in non-apoptotic cells.

KRas, in addition to Tp53 is a driver for early carcinogenesis and a molecular target in a mouse model of invasive gastro-esophageal adenocarcinoma

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.