Author

George Church

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Adrian Briggs· 1 shared Alex Ng· 1 shared Aric Lu· 1 shared Charleston NobleiD· 1 shared Daniel Goodman· 1 shared David CoxiD· 1 shared Emal Lesha· 1 shared Feng Zhang· 1 shared

Activity by Year

2016-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBioengineering

Adrian Briggs

Mutual co-authors in cluster

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3 papers

Recent·Most cited

An orthogonal differentiation platform for genomically programming stem cells, organoids, and bioprinted tissues

Mark Skylar-Scott, Jeremy Huang, Aric Lu, Alex Ng, Tomoya Duenki, Lucy Nam, Sarita Damaraju, George Church, Jennifer A. Lewis

This paper introduces a platform for genomically programming stem cells, organoids, and bioprinted tissues to achieve controlled composition and organization of multiple cell types.

bioRxiv · Jul 11, 2020 · PreprintBioengineering

Evolutionary dynamics of CRISPR gene drives

Charleston Noble, Jason Olejarz, Kevin Esvelt, George Church, Martin Nowak

This study mathematically analyzes the evolutionary dynamics of CRISPR gene drives and shows that resistance alleles challenge their effectiveness, but an alternative design improves stability.

Science Advances · Apr 7, 2017Peer-reviewedSynthetic Biology

Genome Editing With Targeted Deaminases

Luhan Yang, Adrian Briggs, Wei Leong Chew, Prashant Mali, Marc Guell, John Aach, Daniel Goodman, David Cox, Yinan Kan, Emal Lesha, Venkataramanan Soundararajan, Feng Zhang, George Church

This paper introduces targeted deaminases for site-specific C-to-T genomic edits without DNA cleavage, achieving 13% efficiency in E. coli and 2.5% in human cells with reduced toxicity.

Nature Communications · Nov 2, 2016Peer-reviewedBioengineering