Structural basis for alternative 3' splice site selection in the human spliceosome active center
Gabriele Marcianò, Simon Eckert, Luiza Zuvanonv, Takero Miyagawa, Leo Yang, George Datcu, Yuewen Sheng, Hye Young Kwon, Louis Cameron, Florian Heyd, Sebastian M. Fica
The paper presents cryo-EM structures of human spliceosomes showing how SDE2, FAM32A, and Prp18 regulate 3' splice site selection by counteracting distal bias and stabilizing weaker proximal sites.
bioRxiv · Aug 6, 2026 · PreprintMolecular Biology