Author

Takero Miyagawa

University of Oxford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Organism:mouse· 1

Frequent Co-Authors

Sebastian M. FicaiD· 3 shared Abigail R. MoyeiD· 1 shared Aline AntonioiD· 1 shared Andrea Zanetti· 1 shared Andrew Webster· 1 shared Anna M. Boguszewska‐ChachulskaiD· 1 shared Anthony RongvauxiD· 1 shared Axia SongiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Sebastian M. FicaORCID

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Author profile →

3 papers

Recent·Most cited

Biallelic germline variants in the hematologic malignancy predisposition gene DDX41 cause retinal dystrophy through dysregulation of retinal homeostasis.

Zoéline Mars, Andrea Zanetti, Karolina Kamińska, Takero Miyagawa, Duanya Liu, Aline Antonio, Gavin Arno, Isabelle S. Audo, Carmen Ayuso, Hafiz Muhammad Jafar Hussain, Xuan Bao, Pilar Barberán-Martínez, Béatrice Bocquet, Anna M. Boguszewska‐Chachulska, Christel Condroyer, , Isabelle Perrault

The paper identifies biallelic DDX41 variants in LCA/EOSRD patients and shows they disrupt retinal homeostasis through loss-of-function mechanisms in mouse models.

Genome Medicine · Oct 31, 2026Peer-reviewedGenetic & Genomic Medicine

Somatic DDX41 mutations confer neomorphic splicing activity in the pathogenesis of myelodysplastic neoplasms

Rasika Venkataraman, Noemi Puccio, Tun‐Yun Hsueh, Elizabeth A. Bonner, Fu-Yen Chang, Erica A. Arriaga-Gomez, Axia Song, Takero Miyagawa, Jahan A. Rahman, Oluwanifemi Akinwande, Sayantani Sinha, Ettaib El Marabti, Robert S. Welner, Rui Lu, Paul Brent Ferrell, , Stanley Chun-Wei Lee

This study identifies somatic DDX41 mutations as gain-of-function alleles that drive aberrant splicing, particularly of SEPTIN7, contributing to MDS/AML pathogenesis.

bioRxiv · Sep 24, 2026 · PreprintCancer Biology

Structural basis for alternative 3' splice site selection in the human spliceosome active center

Gabriele Marcianò, Simon Eckert, Luiza Zuvanonv, Takero Miyagawa, Leo Yang, George Datcu, Yuewen Sheng, Hye Young Kwon, Louis Cameron, Florian Heyd, Sebastian M. Fica

The paper presents cryo-EM structures of human spliceosomes showing how SDE2, FAM32A, and Prp18 regulate 3' splice site selection by counteracting distal bias and stabilizing weaker proximal sites.

bioRxiv · Aug 6, 2026 · PreprintMolecular Biology