Florian Heyd

The paper presents cryo-EM structures of human spliceosomes showing how SDE2, FAM32A, and Prp18 regulate 3' splice site selection by counteracting distal bias and stabilizing weaker proximal sites.

This study identifies septin-associated PIPKIγ splice variants as essential for midbody organization by generating PI(4,5)P2 required for centralspindlin recruitment and septin-microtubule association.

This paper identifies RNA G-quadruplexes as temperature and potassium sensors that regulate alternative splicing and neuroprotection in subarachnoid hemorrhage.

This study shows that AFC kinases in Arabidopsis regulate warm temperature-responsive growth by controlling splicing patterns and hypocotyl elongation through phosphorylation of SR proteins.

This study compares CDC2-like kinases across eukaryotes, showing their evolutionary conservation, thermo-sensitive properties, and role in alternative splicing regulation.

Inducing cold shock protein RBM3 by modulating its alternative splicing at normothermia is neuroprotective in vivo.

The paper identifies primate-specific CAMK2B splice variants regulated by branch point weakening, showing their role in long-term potentiation and learning.

The paper shows that temperature-dependent alternative splicing couples with nonsense-mediated decay to control rhythmic gene expression in mammals and plants.