Sustained Delivery of a SARS-CoV-2 Subunit Vaccine in An Adjuvanted Hydrogel Depot Enhances Vaccine Responses in Nonhuman Primates
Ben S. Ou, Mengyun Hu, Jerry Yan, Jordan M. Santagata, Olivia M. Saouaf, Haleigh B. Eppler, Victor Lujan, Ye Eun Song, Alba Grifoni, John H. Klich, Alessandro Sette, Ashley Utz, Mehul S. Suthar, Noah Eckman, Yupeng Feng, , Eric Andrew Appel
This study shows that sustained delivery of a SARS-CoV-2 subunit vaccine in an adjuvanted hydrogel depot improves antibody responses in nonhuman primates compared to bolus vaccination.
bioRxiv · Jul 20, 2026 · PreprintBioengineering