Noah Eckman

Cross-Molecular Active Learning for the Discovery of Antimicrobial Polyacrylamides

This paper develops antimicrobial polyacrylamides using a cross-molecular machine learning pipeline trained on antimicrobial peptides, showing synergy with clinical drugs against E. coli biofilms.

Sustained Delivery of a SARS-CoV-2 Subunit Vaccine in An Adjuvanted Hydrogel Depot Enhances Vaccine Responses in Nonhuman Primates

This study shows that sustained delivery of a SARS-CoV-2 subunit vaccine in an adjuvanted hydrogel depot improves antibody responses in nonhuman primates compared to bolus vaccination.

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age-Related Declines in Humoral and Cellular Immunity Relative to Shingrix

This study develops a hydrogel-based vaccine delivery system that enhances immune responses and reduces reactogenicity in aged mice compared to Shingrix.

Structure-Property-Performance Engineering of Hydrogel Depots for Long-Acting Peptide Delivery

This paper develops a hydrogel depot system for long-acting peptide delivery, showing sustained release and improved therapeutic outcomes in rodents.

Long-acting hydrogel-based depot formulations of tirzepatide and semaglutide for the management of type 2 diabetes and weight

This paper develops long-acting hydrogel-based depot formulations of semaglutide and tirzepatide that maintain drug levels for over 6 weeks in a rat model, showing similar efficacy to daily injections.

Intranasal sertraline for the investigation of nose-to-brain delivery to mitigate systemic exposure

This study develops intranasal sertraline formulations to reduce systemic exposure while maintaining brain delivery, showing comparable brain exposure at half the dose compared to oral administration in mice.

A Transient Immunostimulatory Niche Synergizes Adoptive and Endogenous Immunity for Enhanced Tumor Control

This paper develops ACTIVATE, a hydrogel-based platform that enhances tumor control by synergizing adoptive and endogenous immunity through localized cytokine delivery and T-cell activation.

Glassy Surfactants Enable Ultra-High Concentration Biologic Therapeutics

This paper develops a subcutaneous delivery platform for ultra-high-concentration protein therapeutics using a copolymer excipient, enabling reduced injection volumes and improved stability.

Engineering Sustained-Release Broadly Neutralizing Antibody Formulations

This paper develops a hydrogel depot system to prolong the release of broadly neutralizing antibodies, showing improved pharmacokinetics and reduced immune cell-mediated release through co-formulation with anti-inflammatory agents.

Generation of an inflammatory niche in an injectable hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines

This paper improves mRNA vaccine efficacy by creating an inflammatory immune niche via injectable hydrogel depots that recruit immune cells and enhance humoral responses.

Highly extensible physically crosslinked hydrogels for high-speed 3D bioprinting

This study develops a highly extensible hydrogel bioink for high-speed 3D bioprinting, showing significant improvements in print speed and resolution.

Defining Structure-Function Relationships of Amphiphilic Excipients Enables Rational Design of Ultra-Stable Biopharmaceuticals

The paper designs ultra-stable biopharmaceutical excipients by analyzing structure-function relationships of amphiphilic polymers, significantly improving insulin stability.

Dynamic Hydrogel Crosslink Strength Controls Yielding Characteristics and Cell Viability During Injection

This study investigates how dynamic hydrogel crosslink strength affects yielding behavior and cell viability during injection, finding that slower yielding transitions enhance cell protection.

A thiol--ene click-based strategy to customize injectable polymer--nanoparticle hydrogel properties for therapeutic delivery

This paper develops a thiol-ene click chemistry strategy to modify HPMC for tunable PNP hydrogel properties, enabling controlled drug and cell delivery.